Human declarative memory
Donderdag 12 april 2007 00:00
- 0 mensen gaan
The kind of memory one ordinarily means when using the term "memory" is declarative memory, which enables us to retrieve consciously past events and facts. After an era when lesion studies have identified the declarative memory system and its essential anatomical structures, functional imaging techniques like functional MRI and electrophysiology have begun to delineate the neural underpinnings of mnemonic operations like the formation of new memories and the retrieval of old ones. Here, I will initially characterize the neural correlates of these transient and short-lasting operations occurring during memory encoding and retrieval. This data will assign specific mnemonic operations to specific substructures of the medial temporal lobe. Thereafter, I will present data shading some light on declarative memory consolidation, a presumably long lasting (set of) operation(s) transforming initial, liable memory traces into stable forms of long-term memory. Implementing prospective study designs, our functional MRI data provide initial confirmation for the time limited role of the hippocampus in human declarative memory. With time, memory retrieval is associated with less and less hippocampal activity but in turn with more and more activity in neocortical brain areas. Thus, these findings, together with data obtained in rodents, may prompt a revision of classical consolidation theory, incorporating a transfer of putative linking nodes from hippocampal to prelimbic prefrontal areas. Moreover, our data is in line with the notion that slow-wave-sleep plays a crucial role in declarative memory consolidation. In conclusion, functional imaging provides a useful tool for assessing the neural correlates of fundamental mnemonic operations. Thus, we might use these techniques in the near future to probe the genetic and biochemical basis of the normal and the impaired declarative memory system.Het bovenstaande is een abstract van het praatje wat gegeven zal worden door Guillen Fernandez. Eventuele wijzigingen in het programma kun je vinden op de website
- Wie:
- Guillen Fernandez
- Wat:
- Exploring the human declarative memory system by functional neuroimaging
- Waar:
- Van Ronnezaal, k2-052 in the LUMC
- Wanneer:
- 12 april van 16:30 tot 17:30
- Kosten:
- geen