Cerebellum-dependent learning
Maandag 7 mei 2007 00:00
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In vitro studies have identified a large number of synaptic plasticity mechanisms in the cerebellum, raising the question of whether and how each mechanism contributes to cerebellum-dependent learning. We are investigating this question through studies of the vestibulo-ocular reflex (VOR), a reflexive eye movement that undergoes cerebellum-dependent adaptive recalibration. With appropriate training, various modifications can be made to the VOR, for example the amplitude of the reflex can be increased or decreased, and the phase (timing) of the eye movement can be advanced or delayed. I will present convergent evidence from behavioral analysis, in vivo electrophysiology, and molecular-genetic approaches that these different components of motor learning depend on different cellular-molecular mechanisms. More generally, our work suggests that there is more than one way to store motor memories in the cerebellum and related circuitry.Zie de website voor eventuele wijzigingen
- Wie:
- Jennifer Raymond
- Wat:
- Semimar lezing
- Waar:
- Ae406, faculteitsgebouw Erasmus MC
- Wanneer:
- 6 mei, 16:00
- Kosten:
- geen